Faculty Profiles

Chaz Langelier, MD, PhD
M_MED-INFD-CORE
Assistant Professor

1700 4th St
San Francisco, CA 94158
415-418-3647
Chaz.Langelier@ucsf.edu

My research addresses the critical need for better infectious disease diagnostics by leveraging metagenomic next generation sequencing (mNGS) to simultaneously evaluate host gene expression, airway microbes and antibiotic resistance genes from a single clinical sample. In addition, my work aims to understand the biology of infectious lung disease by elucidating host, pathogen and environmental factors that influence respiratory infection susceptibility, severity and contribution to lung injury.

Education and Training

Location Degree or Training Specialty Date
University of California San Francisco Clinical Fellowship Infectious Diseases 07/2016
University of California San Francisco Medical Residency Internal Medicine 06/2014
University of Utah M.D., Ph.D. Medicine/Biochemistry 05/2011
Colby College B.A. with honors, summa cum laude Chemistry/Biochemistry 05/2000

Interests

air pollution and respiratory infections, antibiotic resistance, antibiotic stewardship, emerging pathogens, global health, infectious diseases, microbial diagnostics, next generation sequencing, respiratory infections, smoking and respiratory infections

Awards and Honors
2017   Catalyst Award, UCSF CTSI, 2017
2017   Marcus Program in Precision Medicine Innovation Award, George and Judy Marcus Innovation Fund, 2017
2016   K12 Pulmonary Omics Career Development Award, NIH/UCSF, 2016
2016   Nina Ireland Program for Lung Health Innovative Grant Award, UCSF/Nina Ireland Foundation, 2016
2016   IDAC Best Local Fascinating Case Award, Infectious Disease Association of California, 2016
2016   ATS Assembly on Microbiology, TB & Pulmonary Infections Abstract Award, American Thoracic Society, 2016
2016   K Scholar, UCSF CTSI, 2016
2014   Floyd Rector Basic Science Research Award, UCSF Department of Medicine, 2014
2013   Resident Research Funding Award, UCSF CTSI, 2013
2011   Benjamin H. Kean Fellowship in Tropical Medicine, ASTMH, 2011
2009   CROI Young Investigator Award, CROI, 2009
2000   Colby Presidential Scholar, Colby College, 2000
2000   Phi Beta Kappa, Colby College, Phi Beta Kappa, 2000

In the News

Recent Articles (23)

Bhakta NR, Christenson SA, Nerella S, Solberg OD, Nguyen CP, Choy DF, Jung KL, Garudadri S, Bonser LR, Pollack JL, Zlock LT, Erle DJ, Langelier C, Derisi JL, Arron JR, Fahy JV, Woodruff PG. Interferon-stimulated Gene Expression, Type-2 Inflammation and Endoplasmic Reticulum Stress in Asthma. Am J Respir Crit Care Med. 2017 Oct 24.

Panzer AR, Lynch SV, Langelier C, Christie JD, McCauley K, Nelson M, Cheung CK, Benowitz NL, Cohen MJ, Calfee CS. Lung Microbiota is Related to Smoking Status and to Development of ARDS in Critically Ill Trauma Patients. Am J Respir Crit Care Med. 2017 Oct 16.

Langelier C, Zinter MS, Kalantar K, Yanik GA, Christenson S, O'Donovan B, White C, Wilson M, Sapru A, Dvorak CC, Miller S, Chiu CY, DeRisi JL. Metagenomic Sequencing Detects Respiratory Pathogens in Hematopoietic Cellular Transplant Patients. Am J Respir Crit Care Med. 2017 Jul 07.

Trang TP, Hanretty AM, Langelier C, Yang K. Use of isavuconazole in a patient with voriconazole-induced QTc prolongation. Transpl Infect Dis. 2017 Aug; 19(4).

Ludington WB, Seher TD, Applegate O, Li X, Kliegman JI, Langelier C, Atwill ER, Harter T, DeRisi JL. Assessing biosynthetic potential of agricultural groundwater through metagenomic sequencing: A diverse anammox community dominates nitrate-rich groundwater. PLoS One. 2017; 12(4):e0174930.

Brown L, Langelier C, Reid MJ, Rutishauser RL, Strnad L. Antimicrobial Resistance: A Call to Action! Clin Infect Dis. 2017 Jan 01; 64(1):106-107.

Sircar AD, Abanyie F, Blumberg D, Chin-Hong P, Coulter KS, Cunningham D, Huskins WC, Langelier C, Reid M, Scott BJ, Shirley DA, Babik JM, Belova A, Sapp SG, McAuliffe I, Rivera HN, Yabsley MJ, Montgomery SP. Raccoon Roundworm Infection Associated with Central Nervous System Disease and Ocular Disease - Six States, 2013-2015. MMWR Morb Mortal Wkly Rep. 2016 Sep 09; 65(35):930-3.

Langelier C, Reid MJ, Halabi C, Witek N, LaRiviere A, Shah M, Wilson MR, Chin-Hong P, Douglas V, Kazacos KR, Babik JM. Baylisascaris procyonis-Associated Meningoencephalitis in a Previously Healthy Adult, California, USA. Emerg Infect Dis. 2016 08; 22(8):1480-4.

Weinberg JB, Volkheimer AD, Rubach MP, Florence SM, Mukemba JP, Kalingonji AR, Langelier C, Chen Y, Bush M, Yeo TW, Granger DL, Anstey NM, Mwaikambo ED. Monocyte polarization in children with falciparum malaria: relationship to nitric oxide insufficiency and disease severity. Sci Rep. 2016 Jul 07; 6:29151.

Langelier C, Christenson SA. An Expression of Clinical Significance: Exploring the Human Genome to Understand the Variable Response to Rhinovirus. Am J Respir Crit Care Med. 2016 Apr 01; 193(7):710-2.

Greninger AL, Langelier C, Cunningham G, Keh C, Melgar M, Chiu CY, Miller S. Two Rapidly Growing Mycobacterial Species Isolated from a Brain Abscess: First Whole-Genome Sequences of Mycobacterium immunogenum and Mycobacterium llatzerense. J Clin Microbiol. 2015 Jul; 53(7):2374-7.

Langelier C, Baxi SM, Iribarne D, Chin-Hong P. Beyond the superficial: Coccidioides immitis fungaemia in a man with fever, fatigue and skin nodules: a case of an emerging and evolving pathogen. BMJ Case Rep. 2014 Sep 16; 2014.

Li R, Faden DL, Fakhry C, Langelier C, Jiao Y, Wang Y, Wilkerson MD, Pedamallu CS, Old M, Lang J, Loyo M, Ahn SM, Tan M, Gooi Z, Chan J, Richmon J, Wood LD, Hruban RH, Bishop J, Westra WH, Chung CH, Califano J, Gourin CG, Bettegowda C, Meyerson M, Papadopoulos N, Kinzler KW, Vogelstein B, DeRisi JL, Koch WM, Agrawal N. Clinical, genomic, and metagenomic characterization of oral tongue squamous cell carcinoma in patients who do not smoke. Head Neck. 2015 Nov; 37(11):1642-9.

Rutishauser RL, Langelier C, Baxi SM, Hanks D, Chin-Hong P. Think global, act local: chronic dysuria and sterile pyuria in an Eritrean-American woman. BMJ Case Rep. 2014 Feb 11; 2014.

Lamorte L, Titolo S, Lemke CT, Goudreau N, Mercier JF, Wardrop E, Shah VB, von Schwedler UK, Langelier C, Banik SS, Aiken C, Sundquist WI, Mason SW. Discovery of novel small-molecule HIV-1 replication inhibitors that stabilize capsid complexes. Antimicrob Agents Chemother. 2013 Oct; 57(10):4622-31.

Bajorek M, Schubert HL, McCullough J, Langelier C, Eckert DM, Stubblefield WM, Uter NT, Myszka DG, Hill CP, Sundquist WI. Structural basis for ESCRT-III protein autoinhibition. Nat Struct Mol Biol. 2009 Jul; 16(7):754-62.

Langelier CR, Sandrin V, Eckert DM, Christensen DE, Chandrasekaran V, Alam SL, Aiken C, Olsen JC, Kar AK, Sodroski JG, Sundquist WI. Biochemical characterization of a recombinant TRIM5alpha protein that restricts human immunodeficiency virus type 1 replication. J Virol. 2008 Dec; 82(23):11682-94.

De Domenico I, Ward DM, Langelier C, Vaughn MB, Nemeth E, Sundquist WI, Ganz T, Musci G, Kaplan J. The molecular mechanism of hepcidin-mediated ferroportin down-regulation. Mol Biol Cell. 2007 Jul; 18(7):2569-78.

Alam SL, Langelier C, Whitby FG, Koirala S, Robinson H, Hill CP, Sundquist WI. Structural basis for ubiquitin recognition by the human ESCRT-II EAP45 GLUE domain. Nat Struct Mol Biol. 2006 Nov; 13(11):1029-30.

Langelier C, von Schwedler UK, Fisher RD, De Domenico I, White PL, Hill CP, Kaplan J, Ward D, Sundquist WI. Human ESCRT-II complex and its role in human immunodeficiency virus type 1 release. J Virol. 2006 Oct; 80(19):9465-80.

Veranth JM, Reilly CA, Veranth MM, Moss TA, Langelier CR, Lanza DL, Yost GS. Inflammatory cytokines and cell death in BEAS-2B lung cells treated with soil dust, lipopolysaccharide, and surface-modified particles. Toxicol Sci. 2004 Nov; 82(1):88-96.

Chepanoske CL, Langelier CR, Chmiel NH, David SS. Recognition of the nonpolar base 4-methylindole in DNA by the DNA repair adenine glycosylase MutY. Org Lett. 2000 May 04; 2(9):1341-4.

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