Faculty Profiles

Sharof Tugizov, PhD

513 Parnassus Ave, Med Sci
San Francisco, CA 94143

My current research focuses on the interactions of human viruses, including human immunodeficiency virus and Epstein-Barr virus with oropharyngeal mucosal epithelium. Specifically, I investigate the molecular mechanisms of transepithelial transmission of these viruses through the mucosal epithelium. Understanding viral transmission via the mucosal epithelium is important for preventing the initial steps of viral infection.

Education and Training

Location Degree or Training Specialty Date
University of California, San Francisco Postdoctoral Studies Graduate Division

Related Web Sites

Recent Articles (47)

Wechsler EI, Tugizov S, Herrera R, Da Costa M, Palefsky JM. E5 can be expressed in anal cancer and leads to epidermal growth factor receptor-induced invasion in a human papillomavirus 16-transformed anal epithelial cell line. J Gen Virol. 2018 Apr 06.

Yasen A, Herrera R, Rosbe K, Lien K, Tugizov SM. HIV internalization into oral and genital epithelial cells by endocytosis and macropinocytosis leads to viral sequestration in the vesicles. Virology. 2018 Feb; 515:92-107.

Yasen A, Herrera R, Rosbe K, Lien K, Tugizov SM. Release of HIV-1 sequestered in the vesicles of oral and genital mucosal epithelial cells by epithelial-lymphocyte interaction. PLoS Pathog. 2017 Feb; 13(2):e1006247.

Haga T, Efird JT, Tugizov S, Palefsky JM. Increased TNF-alpha and sTNFR2 levels are associated with high-grade anal squamous intraepithelial lesions in HIV-positive patients with low CD4 level. Papillomavirus Res. 2017 Jun; 3:1-6.

Herrera R, Morris M, Rosbe K, Feng Z, Weinberg A, Tugizov S. Human beta-defensins 2 and -3 cointernalize with human immunodeficiency virus via heparan sulfate proteoglycans and reduce infectivity of intracellular virions in tonsil epithelial cells. Virology. 2016 Jan; 487:172-87.

Sufiawati I, Tugizov SM. HIV-associated disruption of tight and adherens junctions of oral epithelial cells facilitates HSV-1 infection and spread. PLoS One. 2014; 9(2):e88803.

Tugizov SM, Herrera R, Chin-Hong P, Veluppillai P, Greenspan D, Michael Berry J, Pilcher CD, Shiboski CH, Jay N, Rubin M, Chein A, Palefsky JM. HIV-associated disruption of mucosal epithelium facilitates paracellular penetration by human papillomavirus. Virology. 2013 Nov; 446(1-2):378-88.

Tugizov SM, Herrera R, Palefsky JM. Epstein-Barr virus transcytosis through polarized oral epithelial cells. J Virol. 2013 Jul; 87(14):8179-94.

Tugizov SM, Herrera R, Veluppillai P, Greenspan D, Soros V, Greene WC, Levy JA, Palefsky JM. Differential transmission of HIV traversing fetal oral/intestinal epithelia and adult oral epithelia. J Virol. 2012 Mar; 86(5):2556-70.

Challacombe SJ, Fidel PL, Tugizov S, Tao L, Wahl SM. HIV infection and specific mucosal immunity: workshop 4B. Adv Dent Res. 2011 Apr; 23(1):142-51.

Tugizov SM, Webster-Cyriaque JY, Syrianen S, Chattopadyay A, Sroussi H, Zhang L, Kaushal A. Mechanisms of viral infections associated with HIV: workshop 2B. Adv Dent Res. 2011 Apr; 23(1):130-6.

Weinberg A, Naglik JR, Kohli A, Tugizov SM, Fidel PL, Liu Y, Herzberg M. Innate immunity including epithelial and nonspecific host factors: workshop 1B. Adv Dent Res. 2011 Apr; 23(1):122-9.

Tugizov SM, Herrera R, Veluppillai P, Greenspan D, Soros V, Greene WC, Levy JA, Palefsky JM. HIV is inactivated after transepithelial migration via adult oral epithelial cells but not fetal epithelial cells. Virology. 2011 Jan 20; 409(2):211-22.

Dorner M, Zucol F, Alessi D, Haerle SK, Bossart W, Weber M, Byland R, Bernasconi M, Berger C, Tugizov S, Speck RF, Nadal D. beta1 integrin expression increases susceptibility of memory B cells to Epstein-Barr virus infection. J Virol. 2010 Jul; 84(13):6667-77.

Xiao J, Palefsky JM, Herrera R, Sunshine C, Tugizov SM. EBV-positive human sera contain antibodies against the EBV BMRF-2 protein. Virology. 2009 Oct 10; 393(1):151-9.

Xiao J, Palefsky JM, Herrera R, Berline J, Tugizov SM. EBV BMRF-2 facilitates cell-to-cell spread of virus within polarized oral epithelial cells. Virology. 2009 Jun 05; 388(2):335-43.

Haga T, Uchide N, Tugizov S, Palefsky JM. Role of E-cadherin in the induction of apoptosis of HPV16-positive CaSki cervical cancer cells during multicellular tumor spheroid formation. Apoptosis. 2008 Jan; 13(1):97-108.

Xiao J, Palefsky JM, Herrera R, Berline J, Tugizov SM. The Epstein-Barr virus BMRF-2 protein facilitates virus attachment to oral epithelial cells. Virology. 2008 Jan 20; 370(2):430-42.

Tugizov S, Herrera R, Veluppillai P, Greenspan J, Greenspan D, Palefsky JM. Epstein-Barr virus (EBV)-infected monocytes facilitate dissemination of EBV within the oral mucosal epithelium. J Virol. 2007 Jun; 81(11):5484-96.

Xiao J, Palefsky JM, Herrera R, Tugizov SM. Characterization of the Epstein-Barr virus glycoprotein BMRF-2. Virology. 2007 Mar 15; 359(2):382-96.

Tugizov S, Berline J, Herrera R, Penaranda ME, Nakagawa M, Palefsky J. Inhibition of human papillomavirus type 16 E7 phosphorylation by the S100 MRP-8/14 protein complex. J Virol. 2005 Jan; 79(2):1099-112.

Tugizov SM, Berline JW, Palefsky JM. Epstein-Barr virus infection of polarized tongue and nasopharyngeal epithelial cells. Nat Med. 2003 Mar; 9(3):307-14.

Tugizov S, Maidji E, Xiao J, Pereira L. An acidic cluster in the cytosolic domain of human cytomegalovirus glycoprotein B is a signal for endocytosis from the plasma membrane. J Virol. 1999 Oct; 73(10):8677-88.

Tugizov S, Maidji E, Xiao J, Zheng Z, Pereira L. Human cytomegalovirus glycoprotein B contains autonomous determinants for vectorial targeting to apical membranes of polarized epithelial cells. J Virol. 1998 Sep; 72(9):7374-86.

Maidji E, Tugizov S, Abenes G, Jones T, Pereira L. A novel human cytomegalovirus glycoprotein, gpUS9, which promotes cell-to-cell spread in polarized epithelial cells, colocalizes with the cytoskeletal proteins E-cadherin and F-actin. J Virol. 1998 Jul; 72(7):5717-27.

Navarro D, Lennette E, Tugizov S, Pereira L. Humoral immune response to functional regions of human cytomegalovirus glycoprotein B. J Med Virol. 1997 Aug; 52(4):451-9.

Maidji E, Tugizov S, Jones T, Zheng Z, Pereira L. Accessory human cytomegalovirus glycoprotein US9 in the unique short component of the viral genome promotes cell-to-cell transmission of virus in polarized epithelial cells. J Virol. 1996 Dec; 70(12):8402-10.

Zheng Z, Maidji E, Tugizov S, Pereira L. Mutations in the carboxyl-terminal hydrophobic sequence of human cytomegalovirus glycoprotein B alter transport and protein chaperone binding. J Virol. 1996 Nov; 70(11):8029-40.

Tugizov S, Maidji E, Pereira L. Role of apical and basolateral membranes in replication of human cytomegalovirus in polarized retinal pigment epithelial cells. J Gen Virol. 1996 Jan; 77 ( Pt 1):61-74.

Tugizov S, Wang Y, Qadri I, Navarro D, Maidji E, Pereira L. Mutated forms of human cytomegalovirus glycoprotein B are impaired in inducing syncytium formation. Virology. 1995 Jun 01; 209(2):580-91.

Ramakrishnan M, Tugizov S, Pereira L, Lee AS. Conformation-defective herpes simplex virus 1 glycoprotein B activates the promoter of the grp94 gene that codes for the 94-kD stress protein in the endoplasmic reticulum. DNA Cell Biol. 1995 May; 14(5):373-84.

Pereira L, Maidji E, Tugizov S, Jones T. Deletion mutants in human cytomegalovirus glycoprotein US9 are impaired in cell-cell transmission and in altering tight junctions of polarized human retinal pigment epithelial cells. Scand J Infect Dis Suppl. 1995; 99:82-7.

Tugizov S, Navarro D, Paz P, Wang Y, Qadri I, Pereira L. Function of human cytomegalovirus glycoprotein B: syncytium formation in cells constitutively expressing gB is blocked by virus-neutralizing antibodies. Virology. 1994 Jun; 201(2):263-76.

Navarro D, Paz P, Tugizov S, Topp K, La Vail J, Pereira L. Glycoprotein B of human cytomegalovirus promotes virion penetration into cells, transmission of infection from cell to cell, and fusion of infected cells. Virology. 1993 Nov; 197(1):143-58.

Tugizov SM, Savchenkova IP, Grabovskaya IL, Makarova NE, Eraizer TL, Revazova EP, Kushch AA. Changes in expression of surface and core antigens of hepatitis B virus in different mutant clones of hepatoma PLC-PRF-5 cells. Virus Res. 1993 Nov; 30(2):189-203.

Grabovskaya IL, Tugizov SM, Glukhova LA, Kushch AA. Cytogenetic analysis of human hepatocarcinoma cell line PLC-PRF-5 and its mutant clones with different degrees of cell differentiation. Cancer Genet Cytogenet. 1993 Feb; 65(2):147-51.

Shumai EP, Vorob'ev SM, Makarova NE, Tugizov ShM, Zverev VV, Kushch AA. [The immunoenzyme detection of the HIV-1 antigen by using monoclonal antibodies to protein p24]. Vopr Virusol. 1992 Sep-Dec; 37(5-6):229-32.

Tugizov ShM, Savchenkova IP, Grabovskaia IL, Kushch AA. [Changes in the gene expression of the hepatitis B virus in PLC-PRF-5 cells of human hepatocarcinoma during their acquisition of drug resistance]. Vopr Virusol. 1992 Sep-Dec; 37(5-6):238-41.

Kushch AA, Tugizov ShM, Terletskaia EN, Posevaia TA, Nikitina AA, L'vov ND, Barinskii IF. [Human hybridoma neutralizing antibodies to the herpes simplex virus]. Vopr Virusol. 1992 Sep-Dec; 37(5-6):264-6.

Filatov FP, Tugizov ShM, Savchenkova IP, Kumarev VP, Belikov AS, Kadoshnikov IuP, Kush AA, Uryvaev LV. [Recombinant surface proteins of the hepatitis B virus, exhibiting the immunodominant membrane protein of the HIV-1 virus]. Dokl Akad Nauk. 1992; 327(1):172-5.

El'bert LB, Vorovich MF, Terletskaia EN, Lisitsina EA, Atanadze SN, Sidorovich IG, Khozinskii VV, Tugizov ShM, Kushch AA, Khapchaev IuKh. [The protective activity of preparations made from the tick-borne encephalitis virus grown using different cell cultures]. Zh Mikrobiol Epidemiol Immunobiol. 1992 Jan; (1):25-8.

Shpilevaia MV, Tugizov ShM, Kushch AA, Tsilinskii IaIa, Makarova NE. [The biological and immunochemical properties of monoclonal antibodies to the Venezuelan equine encephalomyelitis virus]. Vopr Virusol. 1991 Nov-Dec; 36(6):495-8.

Kushch AA, Tugizov ShM, Simonov VI, Timofeev IV, Perminova NP, Shumai EP. [The properties of monoclonal antibodies to HIV gag gene proteins]. Vopr Virusol. 1991 Jul-Aug; 36(4):275-7.

Vorovitch MF, Timofeev AV, Atanadze SN, Tugizov SM, Kushch AA, Elbert LB. pH-dependent fusion of tick-borne encephalitis virus with artificial membranes. Arch Virol. 1991; 118(1-2):133-8.

Vorovich MF, Timofeev AV, Atanadze SN, Tugizov ShM, Sidorovich IG, Khozinskii VV, Kushch AA, El'bert LB. [The inhibition of the pH-dependent fusion of the tick-borne encephalitis virus with artificial membranes by using non-neutralizing monoclonal antibodies]. Dokl Akad Nauk SSSR. 1991; 316(1):231-4.

Kushch AA, Beliavskii AV, Shumai EP, Tugizov ShM, Ovcharenko AV. [Monoclonal antibodies against topoisomerase I inhibit cell entering into the phase of DNA synthesis]. Dokl Akad Nauk SSSR. 1988; 300(4):968-71.

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