Faculty ProfilesJoel Palefsky, MD
513 Parnassus Ave, Med Sci
San Francisco, CA 94143
Joel Palefsky, M.D.
Infectious Disease Specialist, Professor of Medicine and Laboratory Medicine
Dr. Joel Palefsky is the Chair of the HPV Working Group of the AMC and is the head of the AMC HPV Virology Core Lab. He has extensive experience in studying the biology of HPV infection, HPV infection in HIV-positive men and women, HPV vaccines and in the design and implementation of clinical research trials of HPV-related disease. He has published over 250 papers and is the PI on several laboratory-based and clinical research studies of HPV-associated neoplasia, particularly in the setting of HIV infection. Anal dysplasia occurs in men and women and is especially common among patients infected with the human immunodeficiency virus (HIV). He also specializes in the biology and development of new treatments for HPV and Epstein-Barr virus. He is the founder and president of the International Anal Neoplasia Society and President-elect of the International Human Papillomavirus Society. He is actively involved in training students in clinical and translational research and has led the Doris Duke Charitable Foundation (DDCF) program at UCSF since its inception in 2001. He was the head of the Roadmap T32 student research program in 2005 before it transitioned to the TL1 program, and has been the leader of the Clinical Translational Science Awards (CTSA) TL1 program at UCSF since its inception in 2006. Dr. Palefsky plays an active role in promoting student research programs at UCSF, advising and recruiting students supervising their research and providing active career guidance. He has won numerous student teaching awards.
In the News
Recent Articles (273)
Oral Lopinavir Use and Human Papillomavirus Infection in HIV-Positive Women. J Acquir Immune Defic Syndr. 2015 Oct 1; 70(2):e63-6.
Associations of Anogenital Low-Risk Human Papillomavirus Infection With Cancer and Acquisition of HIV. Sex Transm Dis. 2015 Oct; 42(10):541-4.
Methods in HPV Surveillance: Experiences from a Population-Based Study of HPV Infection among Women in the San Juan Metropolitan Area of Puerto Rico. P R Health Sci J. 2015 Sep; 34(3):117-27.
Prevalence and Correlates of Penile HPV Infection in a Clinic-Based Sample of Hispanic Males. P R Health Sci J. 2015 Sep; 34(3):128-34.
Incidence and Predictors of Abnormal Anal Cytology Findings Among HIV-Infected Adults Receiving Contemporary Antiretroviral Therapy. J Infect Dis. 2016 Feb 1; 213(3):351-60.
Screening to prevent anal cancer: Current thinking and future directions. Cancer Cytopathol. 2015 Sep; 123(9):509-10.
Cervical Precancer Risk in HIV-Infected Women Who Test Positive for Oncogenic Human Papillomavirus Despite a Normal Pap Test. Clin Infect Dis. 2015 Nov 15; 61(10):1573-81.
Immunogenicity and safety of the 9-valent HPV vaccine in men. Vaccine. 2015 Nov 27; 33(48):6892-901.
Screening for Anal Cancer in Women. J Low Genit Tract Dis. 2015 Jul; 19(3 Suppl 1):S26-41.
Prevention of anal cancer - can we do better? Dis Colon Rectum. 2015 May; 58(5):e76.
Rationale and design of a long term follow-up study of women who did and did not receive HPV 16/18 vaccination in Guanacaste, Costa Rica. Vaccine. 2015 Apr 27; 33(18):2141-51.
Human Papillomavirus in the HIV-Infected Host: Epidemiology and Pathogenesis in the Antiretroviral Era. Curr HIV/AIDS Rep. 2015 Mar; 12(1):6-15.
Human papillomavirus knowledge, vaccine acceptance, and vaccine series completion among female entertainment and sex workers in Phnom Penh, Cambodia: the Young Women's Health Study. Int J STD AIDS. 2015 Oct; 26(12):893-902.
Oral human papillomavirus infection among drug users in Puerto Rico. P R Health Sci J. 2014 Dec; 33(4):190-6.
Long-term cumulative detection of human papillomavirus among HIV seropositive women. AIDS. 2014 Nov 13; 28(17):2601-8.
Risk factors for anal HPV-16/18 infection in Mexican HIV-infected men who have sex with men. Prev Med. 2014 Dec; 69:157-64.
Cervical human papillomavirus testing to triage borderline abnormal pap tests in HIV-coinfected women. AIDS. 2014 Jul 17; 28(11):1696-8.
Genital tract HIV RNA levels and their associations with human papillomavirus infection and risk of cervical precancer. J Acquir Immune Defic Syndr. 2014 Jul 1; 66(3):316-23.
Incidence of and risk factors for type-specific anal human papillomavirus infection among HIV-positive MSM. AIDS. 2014 Jun 1; 28(9):1341-9.
Geographical distribution and risk association of human papillomavirus genotype 52-variant lineages. J Infect Dis. 2014 Nov 15; 210(10):1600-4.
Human papillomavirus-related cancers among people living with AIDS in Puerto Rico. Prev Chronic Dis. 2014; 11:E80.
Environmental scan of anal cancer screening practices: worldwide survey results. Cancer Med. 2014 Aug; 3(4):1052-61.
Immunogenicity and Safety of the Quadrivalent Human Papillomavirus Vaccine in HIV-1-Infected Women. Clin Infect Dis. 2014 Jul 1; 59(1):127-35.
Who is ready to screen for anal squamous intraepithelial lesions and why should they perform high-resolution anoscopy? Sex Transm Dis. 2014 Apr; 41(4):254-6.
Prevalence and risk factors associated with anal intraepithelial neoplasia among HIV-positive men in Brazil. J Low Genit Tract Dis. 2014 Apr; 18(2):128-35.
Anal cancer trends in Puerto Rico from 1985 to 2005: the potential impact of the AIDS epidemic. AIDS Patient Care STDS. 2014 Apr; 28(4):165-7.
Human papillomavirus types 2, 27, and 57 Identified in plantar verrucae from HIV-positive and HIV-negative individuals. J Am Podiatr Med Assoc. 2014 Mar; 104(2):141-6.
Incidence, clearance, and disease progression of genital human papillomavirus infection in heterosexual men. J Infect Dis. 2014 Jul 15; 210(2):192-9.
The relation of plasmacytoid dendritic cells (pDCs) and regulatory T-cells (Tregs) with HPV persistence in HIV-infected and HIV-uninfected women. Viral Immunol. 2014 Feb; 27(1):20-5.
Epidemiology of anal HPV infection in high-risk men attending a sexually transmitted infection clinic in Puerto Rico. PLoS One. 2014; 9(1):e83209.
HPV vaccination in India. South Asian J Cancer. 2014 Jan; 3(1):93-4.
Prevalence and risk factors for neutralizing antibodies to human papillomavirus types 16 and 18 in HIV-positive men who have sex with men. J Acquir Immune Defic Syndr. 2013 Dec 15; 64(5):479-87.
Recognizing and treating anal cancer: training medical students and physicians in Puerto Rico. P R Health Sci J. 2013 Dec; 32(4):209-12.
Use of human papillomavirus DNA, E6/E7 mRNA, and p16 immunocytochemistry to detect and predict anal high-grade squamous intraepithelial lesions in HIV-positive and HIV-negative men who have sex with men. PLoS One. 2013; 8(11):e78291.
Assessment of HPV 16 and HPV 18 antibody responses by pseudovirus neutralization, Merck cLIA and Merck total IgG LIA immunoassays in a reduced dosage quadrivalent HPV vaccine trial. Vaccine. 2014 Jan 23; 32(5):624-30.
HIV-associated disruption of mucosal epithelium facilitates paracellular penetration by human papillomavirus. Virology. 2013 Nov; 446(1-2):378-88.
Progression of anal high-grade squamous intraepithelial lesions to invasive anal cancer among HIV-infected men who have sex with men. Int J Cancer. 2014 Mar 1; 134(5):1147-55.
Anal human papillomavirus infection among Thai men who have sex with men with and without HIV infection: prevalence, incidence, and persistence. J Acquir Immune Defic Syndr. 2013 Aug 1; 63(4):472-9.
Risk factors for anal human papillomavirus infection type 16 among HIV-positive men who have sex with men in San Francisco. J Acquir Immune Defic Syndr. 2013 Aug 1; 63(4):532-9.
Concomitant anal and cervical human papillomavirusV infections and intraepithelial neoplasia in HIV-infected and uninfected women. AIDS. 2013 Jul 17; 27(11):1743-51.
High prevalence and incidence of high-grade anal intraepithelial neoplasia among young Thai men who have sex with men with and without HIV. AIDS. 2013 Jul 17; 27(11):1753-62.
Trends in the occurrence of high-grade anal intraepithelial neoplasia in San Francisco: 2000-2009. Cancer. 2013 Oct 1; 119(19):3539-45.
Quadrivalent HPV vaccine efficacy against disease related to vaccine and non-vaccine HPV types in males. Vaccine. 2013 Aug 20; 31(37):3849-55.
Epstein-Barr virus transcytosis through polarized oral epithelial cells. J Virol. 2013 Jul; 87(14):8179-94.
Human papillomavirus infection in women in Puerto Rico: agreement between physician-collected and self-collected anogenital specimens. J Low Genit Tract Dis. 2013 Apr; 17(2):210-7.
Cervical human papillomavirus infection in a sample of Hispanic women living in Puerto Rico: comparison with cervical cytology reports. P R Health Sci J. 2013 Mar; 32(1):3-7.
High-grade anal intraepithelial neoplasia among HIV-1-infected men screening for a multicenter clinical trial of a human papillomavirus vaccine. HIV Clin Trials. 2013 Mar-Apr; 14(2):75-9.
Safety and efficacy of topical cidofovir to treat high-grade perianal and vulvar intraepithelial neoplasia in HIV-positive men and women. AIDS. 2013 Feb 20; 27(4):545-51.
The Lower Anogenital Squamous Terminology Standardization project for HPV-associated lesions: background and consensus recommendations from the College of American Pathologists and the American Society for Colposcopy and Cervical Pathology. Int J Gynecol Pathol. 2013 Jan; 32(1):76-115.
Awareness and knowledge of human papillomavirus (HPV) infection among high-risk men of Hispanic origin attending a sexually transmitted infection (STI) clinic. BMC Infect Dis. 2012; 12:346.
Acceptability of cervical and anal HPV self-sampling in a sample of Hispanic women in Puerto Rico. P R Health Sci J. 2012 Dec; 31(4):205-12.
HPV awareness and willingness to HPV vaccination among high-risk men attending an STI clinic in Puerto Rico. P R Health Sci J. 2012 Dec; 31(4):227-31.
Practising high-resolution anoscopy. Sex Health. 2012 Dec; 9(6):580-6.
Geographical distribution and oncogenic risk association of human papillomavirus type 58 E6 and E7 sequence variations. Int J Cancer. 2013 Jun 1; 132(11):2528-36.
Updating the natural history of human papillomavirus and anogenital cancers. Vaccine. 2012 Nov 20; 30 Suppl 5:F24-33.
Human papillomavirus, human immunodeficiency virus and immunosuppression. Vaccine. 2012 Nov 20; 30 Suppl 5:F168-74.
Report of the 2012 capacity building for HIV-HPV clinical trials recruitment among minority underserved populations of Hispanic origin in Puerto Rico. P R Health Sci J. 2012 Sep; 31(3):185-7.
Cervical human papillomavirus infection among young women engaged in sex work in Phnom Penh, Cambodia: prevalence, genotypes, risk factors and association with HIV infection. BMC Infect Dis. 2012; 12:166.
Risk of cervical precancer and cancer among HIV-infected women with normal cervical cytology and no evidence of oncogenic HPV infection. JAMA. 2012 Jul 25; 308(4):362-9.
EUROGIN 2011 roadmap on prevention and treatment of HPV-related disease. Int J Cancer. 2012 Nov 1; 131(9):1969-82.
Antiretroviral therapy and anal cancer: the good, the bad, and the unknown. Sex Transm Dis. 2012 Jul; 39(7):501-3.
The Lower Anogenital Squamous Terminology Standardization Project for HPV-Associated Lesions: background and consensus recommendations from the College of American Pathologists and the American Society for Colposcopy and Cervical Pathology. J Low Genit Tract Dis. 2012 Jul; 16(3):205-42.
Anal cancer screening. Lancet Oncol. 2012 Jul; 13(7):e279-80; author rreply e280.
The Lower Anogenital Squamous Terminology Standardization Project for HPV-Associated Lesions: background and consensus recommendations from the College of American Pathologists and the American Society for Colposcopy and Cervical Pathology. Arch Pathol Lab Med. 2012 Oct; 136(10):1266-97.
HIV protease inhibitors to prevent progression of cervical intraepithelial neoplasia to cervical cancer: therapeutic opportunities and challenges. AIDS. 2012 May 15; 26(8):1035-6.
Anal human papillomavirus infection in a street-based sample of drug using HIV-positive men. Int J STD AIDS. 2012 Mar; 23(3):195-200.
Cervicovaginal human papillomavirus (HPV)-infection before and after hysterectomy: evidence of different tissue tropism for oncogenic and nononcogenic HPV types in a cohort of HIV-positive and HIV-negative women. Int J Cancer. 2012 Sep 15; 131(6):1472-8.
Differential transmission of HIV traversing fetal oral/intestinal epithelia and adult oral epithelia. J Virol. 2012 Mar; 86(5):2556-70.
Immunogenicity of the quadrivalent human papillomavirus (type 6/11/16/18) vaccine in males 16 to 26 years old. Clin Vaccine Immunol. 2012 Feb; 19(2):261-7.
Investigating Potential Associations between Cervical Procedures and HIV Acquisition. ISRN Obstet Gynecol. 2011; 2011:789106.
HPV vaccine against anal HPV infection and anal intraepithelial neoplasia. N Engl J Med. 2011 Oct 27; 365(17):1576-85.
Anal HPV prevalence and associated factors among HIV-seropositive men under antiretroviral treatment in Brazil. J Acquir Immune Defic Syndr. 2011 Aug; 57 Suppl 3:S217-24.
Human papillomavirus in men: an update. J Low Genit Tract Dis. 2011 Jul; 15(3):231-4.
Safety and reactogenicity of a quadrivalent human papillomavirus (types 6, 11, 16, 18) L1 viral-like-particle vaccine in older adolescents and young adults. Hum Vaccin. 2011 Jul; 7(7):768-75.
Identification of human papillomavirus type 58 lineages and the distribution worldwide. J Infect Dis. 2011 Jun 1; 203(11):1565-73.
Validation of a diagnostic microarray for human papillomavirus: coverage of 102 genotypes. J Nucleic Acids. 2011; 2011:756905.
Human papillomavirus infection and cytologic abnormalities of the anus and cervix among HIV-infected women in the study to understand the natural history of HIV/AIDS in the era of effective therapy (the SUN study). Sex Transm Dis. 2011 Apr; 38(4):253-9.
Loss of quality of life associated with genital warts: baseline analyses from a prospective study. Sex Transm Infect. 2011 Apr; 87(3):209-15.
Efficacy of quadrivalent HPV vaccine against HPV Infection and disease in males. N Engl J Med. 2011 Feb 3; 364(5):401-11.
Human papillomavirus 16 (HPV 16) and HPV 18 antibody responses measured by pseudovirus neutralization and competitive Luminex assays in a two- versus three-dose HPV vaccine trial. Clin Vaccine Immunol. 2011 Mar; 18(3):418-23.
External genital human papillomavirus prevalence and associated factors among heterosexual men on 5 continents. J Infect Dis. 2011 Jan 1; 203(1):58-65.
Prevalence of and risk factors for human papillomavirus (HPV) infection among HIV-seronegative men who have sex with men. J Infect Dis. 2011 Jan 1; 203(1):66-74.
HIV is inactivated after transepithelial migration via adult oral epithelial cells but not fetal epithelial cells. Virology. 2011 Jan 20; 409(2):211-22.
Can HPV vaccination help to prevent anal cancer? Lancet Infect Dis. 2010 Dec; 10(12):815-6.
Safety and immunogenicity of the quadrivalent human papillomavirus vaccine in HIV-1-infected men. J Infect Dis. 2010 Oct 15; 202(8):1246-53.
Factors associated with prevalent abnormal anal cytology in a large cohort of HIV-infected adults in the United States. J Infect Dis. 2010 Nov 15; 202(10):1567-76.
Burden of human papillomavirus infection and related comorbidities in men: implications for research, disease prevention and health promotion among Hispanic men. P R Health Sci J. 2010 Sep; 29(3):232-40.
Detection and quantitation of HPV in genital and oral tissues and fluids by real time PCR. Virol J. 2010; 7:194.
Esophageal verrucous carcinoma arising from hyperkeratotic plaques associated with human papilloma virus type 51. Dis Esophagus. 2010 Jul; 23(5):E17-20.
Addition of a single E2 binding site to the human papillomavirus (HPV) type 16 long control region enhances killing of HPV positive cells via HPV E2 protein-regulated herpes simplex virus type 1 thymidine kinase-mediated suicide gene therapy. Hum Gene Ther. 2010 Jul; 21(7):843-54.
Gay and bisexual men's willingness to receive anal Papanicolaou testing. Am J Public Health. 2010 Jun; 100(6):1123-9.
Type-specific cervico-vaginal human papillomavirus infection increases risk of HIV acquisition independent of other sexually transmitted infections. PLoS One. 2010; 5(4):e10094.
Human papillomavirus-related disease in men: not just a women's issue. J Adolesc Health. 2010 Apr; 46(4 Suppl):S12-9.
Influence of adherent and effective antiretroviral therapy use on human papillomavirus infection and squamous intraepithelial lesions in human immunodeficiency virus-positive women. J Infect Dis. 2010 Mar; 201(5):681-90.
Evaluation and Management of Anal Intraepithelial Neoplasia in HIV-Negative and HIV-Positive Men Who Have Sex with Men. Curr Infect Dis Rep. 2010 Mar; 12(2):126-33.
Marijuana use is not associated with cervical human papillomavirus natural history or cervical neoplasia in HIV-seropositive or HIV-seronegative women. Cancer Epidemiol Biomarkers Prev. 2010 Mar; 19(3):869-72.
Prevalence, distribution and correlates of endocervical human papillomavirus types in Brazilian women. Int J STD AIDS. 2010 Feb; 21(2):105-9.
Marginal and mixed-effects models in the analysis of human papillomavirus natural history data. Cancer Epidemiol Biomarkers Prev. 2010 Jan; 19(1):159-69.
Human Immunodeficiency Virus and Human Papilloma Virus - why HPV-induced lesions do not spontaneously resolve and why therapeutic vaccination can be successful. J Transl Med. 2009; 7:108.
Efficacy of trichloroacetic acid in the treatment of anal intraepithelial neoplasia in HIV-positive and HIV-negative men who have sex with men. J Acquir Immune Defic Syndr. 2009 Dec 1; 52(4):474-9.
Invited commentary. Dis Colon Rectum. 2009 Nov; 52(11):1860-3.
Prevalence of human papillomavirus 16 and 18 neutralizing antibodies in prenatal women in British Columbia. Clin Vaccine Immunol. 2009 Dec; 16(12):1840-3.
Anal cancer prevention in HIV-positive men and women. Curr Opin Oncol. 2009 Sep; 21(5):433-8.
EBV-positive human sera contain antibodies against the EBV BMRF-2 protein. Virology. 2009 Oct 10; 393(1):151-9.
Anal human papillomavirus infection is associated with HIV acquisition in men who have sex with men. AIDS. 2009 Jun 1; 23(9):1135-42.
Human papillomavirus type distribution in anal cancer and anal intraepithelial lesions. Int J Cancer. 2009 May 15; 124(10):2375-83.
Cervical human papillomavirus incidence and persistence in a cohort of HIV-negative women in Zimbabwe. Sex Transm Dis. 2009 May; 36(5):305-11.
EBV BMRF-2 facilitates cell-to-cell spread of virus within polarized oral epithelial cells. Virology. 2009 Jun 5; 388(2):335-43.
The epidemiology of anal human papillomavirus and related neoplasia. Obstet Gynecol Clin North Am. 2009 Mar; 36(1):187-200.
Performance characteristics of anal cytology and human papillomavirus testing in patients with high-resolution anoscopy-guided biopsy of high-grade anal intraepithelial neoplasia. Dis Colon Rectum. 2009 Feb; 52(2):239-47.
Anal intraepithelial neoplasia in a multisite study of HIV-infected and high-risk HIV-uninfected women. AIDS. 2009 Jan 2; 23(1):59-70.
Human papilloma virus type 69 identified in a clinically aggressive plantar verruca from an HIV-positive patient. J Am Podiatr Med Assoc. 2009 Jan-Feb; 99(1):8-12.
Human papillomavirus-related disease in people with HIV. Curr Opin HIV AIDS. 2009 Jan; 4(1):52-6.
Substitution of methionine 63 or 83 in S100A9 and cysteine 42 in S100A8 abrogate the antifungal activities of S100A8/A9: potential role for oxidative regulation. FEMS Immunol Med Microbiol. 2009 Jan; 55(1):55-61.
Effect of diaphragm and lubricant gel provision on human papillomavirus infection among women provided with condoms: a randomized controlled trial. Obstet Gynecol. 2008 Nov; 112(5):990-7.
Comparison of patient- and clinician-collected anal cytology samples to screen for human papillomavirus-associated anal intraepithelial neoplasia in men who have sex with men. Ann Intern Med. 2008 Sep 2; 149(5):300-6.
HPV types present in invasive cervical cancers of HIV-seropositive women. Int J Cancer. 2008 Sep 1; 123(5):1224-5.
Factors associated with increased prevalence of human papillomavirus infection in a cohort of HIV-infected Brazilian women. Int J Infect Dis. 2009 Jan; 13(1):72-80.
Behavior surveillance: prevalence and factors associated with high-risk sexual behavior among HIV-infected men in Brazil in the post-HAART era. AIDS Behav. 2008 Sep; 12(5):741-7.
Human papillomavirus and anal neoplasia. Curr HIV/AIDS Rep. 2008 May; 5(2):78-85.
High-resolution anoscopy targeted surgical destruction of anal high-grade squamous intraepithelial lesions: a ten-year experience. Dis Colon Rectum. 2008 Jun; 51(6):829-35; discussion 835-7.
The relationship between cocaine use and human papillomavirus infections in HIV-seropositive and HIV-seronegative women. Infect Dis Obstet Gynecol. 2008; 2008:587082.
Role of E-cadherin in the induction of apoptosis of HPV16-positive CaSki cervical cancer cells during multicellular tumor spheroid formation. Apoptosis. 2008 Jan; 13(1):97-108.
Infrared coagulator treatment of high-grade anal dysplasia in HIV-infected individuals: an AIDS malignancy consortium pilot study. J Acquir Immune Defic Syndr. 2008 Jan 1; 47(1):56-61.
Insulin-like growth factor axis and oncogenic human papillomavirus natural history. Cancer Epidemiol Biomarkers Prev. 2008 Jan; 17(1):245-8.
The Epstein-Barr virus BMRF-2 protein facilitates virus attachment to oral epithelial cells. Virology. 2008 Jan 20; 370(2):430-42.
Association of cutaneous anergy with human papillomavirus and cervical neoplasia in HIV-seropositive and seronegative women. AIDS. 2007 Sep 12; 21(14):1933-41.
High resolution anoscopy in the planned staged treatment of anal squamous intraepithelial lesions in HIV-negative patients. J Gastrointest Surg. 2007 Nov; 11(11):1410-5; discussion 1415-6.
Human papillomavirus infection in HIV-infected persons. Top HIV Med. 2007 Aug-Sep; 15(4):130-3.
Six-month natural history of oral versus cervical human papillomavirus infection. Int J Cancer. 2007 Jul 1; 121(1):143-50.
Epstein-Barr virus (EBV)-infected monocytes facilitate dissemination of EBV within the oral mucosal epithelium. J Virol. 2007 Jun; 81(11):5484-96.
HPV infection in men. Dis Markers. 2007; 23(4):261-72.
Oxidation of methionine 63 and 83 regulates the effect of S100A9 on the migration of neutrophils in vitro. J Leukoc Biol. 2007 Mar; 81(3):818-24.
Characterization of the Epstein-Barr virus glycoprotein BMRF-2. Virology. 2007 Mar 15; 359(2):382-96.
Effect of Replens gel used with a diaphragm on tests for human papillomavirus and other lower genital tract infections. J Low Genit Tract Dis. 2006 Oct; 10(4):213-8.
Relationship of pregnancy to human papillomavirus among human immunodeficiency virus-infected women. Obstet Gynecol. 2006 Oct; 108(4):953-60.
S100A8 triggers oxidation-sensitive repulsion of neutrophils. J Dent Res. 2006 Sep; 85(9):829-33.
Human papillomavirus-related tumors in HIV. Curr Opin Oncol. 2006 Sep; 18(5):463-8.
Molecular cytogenetic characterization of human papillomavirus16-transformed foreskin keratinocyte cell line 16-MT. Cancer Genet Cytogenet. 2006 Jul 1; 168(1):36-43.
Chapter 16: HPV vaccines in immunocompromised women and men. Vaccine. 2006 Aug 31; 24 Suppl 3:S3/140-6.
Screening HIV-infected individuals for anal cancer precursor lesions: a systematic review. Clin Infect Dis. 2006 Jul 15; 43(2):223-33.
A trial of SGN-00101 (HspE7) to treat high-grade anal intraepithelial neoplasia in HIV-positive individuals. AIDS. 2006 May 12; 20(8):1151-5.
Biology of HPV in HIV infection. Adv Dent Res. 2006; 19(1):99-105.
Serological detection of human papillomavirus type 16 infection in human immunodeficiency virus (HIV)-positive and high-risk HIV-negative women. Clin Vaccine Immunol. 2006 Apr; 13(4):511-9.
Advances in prevention of cervical cancer and other human papillomavirus-related diseases. Pediatr Infect Dis J. 2006 Feb; 25(2 Suppl):S65-81, quiz S82.
High-resolution analysis of genomic alterations and human papillomavirus integration in anal intraepithelial neoplasia. J Acquir Immune Defic Syndr. 2005 Oct 1; 40(2):182-9.
Variants of human papillomaviruses 16 and 18 and their natural history in human immunodeficiency virus-positive women. J Gen Virol. 2005 Oct; 86(Pt 10):2709-20.
Anal intraepithelial neoplasia in the highly active antiretroviral therapy era among HIV-positive men who have sex with men. AIDS. 2005 Sep 2; 19(13):1407-14.
Age-related prevalence of anal cancer precursors in homosexual men: the EXPLORE study. J Natl Cancer Inst. 2005 Jun 15; 97(12):896-905.
Natural history and possible reactivation of human papillomavirus in human immunodeficiency virus-positive women. J Natl Cancer Inst. 2005 Apr 20; 97(8):577-86.
Colorectal papillomavirus infection in patients with colorectal cancer. Clin Cancer Res. 2005 Apr 15; 11(8):2862-7.
Incidence of cervical squamous intraepithelial lesions associated with HIV serostatus, CD4 cell counts, and human papillomavirus test results. JAMA. 2005 Mar 23; 293(12):1471-6.
Effects of bacterial vaginosis and other genital infections on the natural history of human papillomavirus infection in HIV-1-infected and high-risk HIV-1-uninfected women. J Infect Dis. 2005 Apr 1; 191(7):1129-39.
Editorial comment: screening and treatment of AIN to prevent anal cancer--where do we stand? AIDS Read. 2005 Feb; 15(2):87.
Inhibition of human papillomavirus type 16 E7 phosphorylation by the S100 MRP-8/14 protein complex. J Virol. 2005 Jan; 79(2):1099-112.
Human papillomavirus anogenital disease in HIV-infected individuals. Dermatol Ther. 2005 Jan-Feb; 18(1):67-76.
Age-Specific prevalence of anal human papillomavirus infection in HIV-negative sexually active men who have sex with men: the EXPLORE study. J Infect Dis. 2004 Dec 15; 190(12):2070-6.
Highly tissue substructure-specific effects of human papilloma virus in mucosa of HIV-infected patients revealed by laser-dissection microscopy-assisted gene expression profiling. Am J Pathol. 2004 Sep; 165(3):707-18.
Self-collected versus clinician-collected anal cytology specimens to diagnose anal intraepithelial neoplasia in HIV-positive men. J Acquir Immune Defic Syndr. 2004 Aug 1; 36(4):915-20.
Highly active antiretroviral therapy and cervical squamous intraepithelial lesions in human immunodeficiency virus-positive women. J Natl Cancer Inst. 2004 Jul 21; 96(14):1070-6.
Human papillomavirus and abnormal Pap test results in Vietnamese-American women: a pilot case-control study. J Low Genit Tract Dis. 2004 Jul; 8(3):217-23.
Anal cancer in HIV infection: to screen or not to screen? AIDS Clin Care. 2004 Jul; 16(7):53-5, 57.
Transcriptional profiling of dysplastic lesions in K14-HPV16 transgenic mice using laser microdissection. FASEB J. 2004 Aug; 18(11):1243-5.
Effect of antiretroviral therapy on the incidence of genital warts and vulvar neoplasia among women with the human immunodeficiency virus. Am J Obstet Gynecol. 2004 May; 190(5):1241-8.
Relationship between smoking and human papillomavirus infections in HIV-infected and -uninfected women. J Infect Dis. 2004 May 15; 189(10):1821-8.
Anal cancer and its precursors in HIV-positive patients: perspectives and management. Surg Oncol Clin N Am. 2004 Apr; 13(2):355-73.
HPV testing for triage of HIV-infected women with papanicolaou smears read as atypical squamous cells of uncertain significance. J Womens Health (Larchmt). 2004 Mar; 13(2):147-53.
High prevalence of anal squamous intraepithelial lesions in HIV-positive men despite the use of highly active antiretroviral therapy. Sex Transm Dis. 2004 Feb; 31(2):96-9.
The impact of HIV antiviral therapy on human papillomavirus (HPV) infections and HPV-related diseases. Antivir Ther. 2004 Feb; 9(1):13-22.
Serum immunoglobulin A response to human papillomavirus type 16 virus-like particles in human immunodeficiency virus (HIV)-positive and high-risk HIV-negative women. J Infect Dis. 2003 Dec 15; 188(12):1834-44.
Cervical human papillomavirus infection and cervical intraepithelial neoplasia in women positive for human immunodeficiency virus in the era of highly active antiretroviral therapy. Curr Opin Oncol. 2003 Sep; 15(5):382-8.
Kidney and liver transplantation in human immunodeficiency virus-infected patients: a pilot safety and efficacy study. Transplantation. 2003 Jul 27; 76(2):370-5.
Human papillomavirus type 16 and immune status in human immunodeficiency virus-seropositive women. J Natl Cancer Inst. 2003 Jul 16; 95(14):1062-71.
Chlamydia trachomatis, herpes simplex virus 2, and human T-cell lymphotrophic virus type 1 are not associated with grade of cervical neoplasia in Jamaican colposcopy patients. Sex Transm Dis. 2003 Jul; 30(7):575-80.
Incidence of anal cytological abnormalities in a cohort of human immunodeficiency virus-infected women. Cancer Epidemiol Biomarkers Prev. 2003 Jul; 12(7):638-42.
Anal cancer: an HIV-associated cancer. Hematol Oncol Clin North Am. 2003 Jun; 17(3):859-72.
A review of human papillomavirus vaccines: from basic science to clinical trials. Front Biosci. 2003 May 1; 8:s333-45.
High prevalence of anal human papillomavirus infection and anal cancer precursors among HIV-infected persons in the absence of anal intercourse. Ann Intern Med. 2003 Mar 18; 138(6):453-9.
Epstein-Barr virus infection of polarized tongue and nasopharyngeal epithelial cells. Nat Med. 2003 Mar; 9(3):307-14.
Serum immunoglobulin G response to human papillomavirus type 16 virus-like particles in human immunodeficiency virus (HIV)-positive and risk-matched HIV-negative women. J Infect Dis. 2003 Jan 15; 187(2):194-205.
Treatment of human papillomavirus (HPV) type 16-infected cells using herpes simplex virus type 1 thymidine kinase-mediated gene therapy transcriptionally regulated by the HPV E2 protein. Hum Gene Ther. 2003 Jan 1; 14(1):45-57.
Chapter 6: Immunosuppression and co-infection with HIV. J Natl Cancer Inst Monogr. 2003; (31):41-6.
Cervical and anal HPV infections in HIV positive women and men. Virus Res. 2002 Nov; 89(2):201-11.
Natural history and clinical management of anal human papillomavirus disease in men and women infected with human immunodeficiency virus. Clin Infect Dis. 2002 Nov 1; 35(9):1127-34.
The impact of HIV infection and immunodeficiency on human papillomavirus type 6 or 11 infection and on genital warts. Sex Transm Dis. 2002 Aug; 29(8):427-35.
Time course of humoral and cell-mediated immune responses to human papillomavirus type 16 in infected women. Clin Diagn Lab Immunol. 2002 Jul; 9(4):877-82.
Is high-grade dysplasia on anal Pap a high-grade problem? AIDS Clin Care. 2002 May; 14(5):44-5.
Encapsulated plasmid DNA treatment for human papillomavirus 16-associated anal dysplasia: a Phase I study of ZYC101. Clin Cancer Res. 2002 May; 8(5):1028-37.
Increased risk of high-grade anal neoplasia associated with a human papillomavirus type 16 E6 sequence variant. J Infect Dis. 2002 May 1; 185(9):1229-37.
Activity of HspE7, a novel immunotherapy, in patients with anogenital warts. Dis Colon Rectum. 2002 Apr; 45(4):502-7.
Surgical treatment of high-grade anal squamous intraepithelial lesions: a prospective study. Dis Colon Rectum. 2002 Apr; 45(4):453-8.
Evidence for trafficking of Epstein-Barr virus strains between hairy leukoplakia and peripheral blood lymphocytes. J Gen Virol. 2002 Feb; 83(Pt 2):317-21.
Effect of highly active antiretroviral therapy on the natural history of anal squamous intraepithelial lesions and anal human papillomavirus infection. J Acquir Immune Defic Syndr. 2001 Dec 15; 28(5):422-8.
Determinants of HIV-1 shedding in the genital tract of women. Lancet. 2001 Nov 10; 358(9293):1593-601.
The effect of highly active antiretroviral therapy on cervical cytologic changes associated with oncogenic HPV among HIV-infected women. AIDS. 2001 Nov 9; 15(16):2157-64.
Risks for incident human papillomavirus infection and low-grade squamous intraepithelial lesion development in young females. JAMA. 2001 Jun 20; 285(23):2995-3002.
Prevalence and risk factors for anal squamous intraepithelial lesions in women. J Natl Cancer Inst. 2001 Jun 6; 93(11):843-9.
High prevalence of anal squamous intraepithelial lesions and squamous-cell carcinoma in men who have sex with men as seen in a surgical practice. Dis Colon Rectum. 2001 May; 44(5):690-8.
Detection of genetic changes in anal intraepithelial neoplasia (AIN) of HIV-positive and HIV-negative men. J Acquir Immune Defic Syndr. 2001 Mar 1; 26(3):256-62.
Prevalence and risk factors for anal human papillomavirus infection in human immunodeficiency virus (HIV)-positive and high-risk HIV-negative women. J Infect Dis. 2001 Feb 1; 183(3):383-91.
Successful treatment of juvenile laryngeal papillomatosis-related multicystic lung disease with cidofovir: case report and review of the literature. Chest. 2000 Oct; 118(4):1210-4.
Association of vitamin A deficiency with cervical squamous intraepithelial lesions in human immunodeficiency virus-infected women. J Infect Dis. 2000 Oct; 182(4):1084-9.
Anal squamous intraepithelial lesions in human immunodeficiency virus-positive men and women. Semin Oncol. 2000 Aug; 27(4):471-9.
Persistence of human papillomavirus type 16 infection is associated with lack of cytotoxic T lymphocyte response to the E6 antigens. J Infect Dis. 2000 Aug; 182(2):595-8.
Integrin expression in oral hairy leukoplakia and normal tongue epithelium. Oral Dis. 2000 Jul; 6(4):234-40.
Type I collagen degradation by invasive oral squamous cell carcinoma. Oral Oncol. 2000 Jul; 36(4):365-72.
Cost-effectiveness of screening for anal squamous intraepithelial lesions and anal cancer in human immunodeficiency virus-negative homosexual and bisexual men. Am J Med. 2000 Jun 1; 108(8):634-41.
Angiogenesis, proliferation, and apoptosis in anal high-grade squamous intraepithelial lesions. Dis Colon Rectum. 2000 Mar; 43(3):346-52.
Human immunodeficiency virus-positive individuals with oral hairy leukoplakia are able to mount cytotoxic T lymphocyte responses to Epstein-Barr virus. Oral Dis. 2000 Jan; 6(1):40-7.
Human papillomavirus-related tumors. AIDS. 2000; 14 Suppl 3:S189-95.
Human herpesvirus 8 cellular immune responses in homosexual men. J Infect Dis. 1999 Nov; 180(5):1682-5.
Adeno-associated virus and development of cervical neoplasia. J Med Virol. 1999 Sep; 59(1):60-5.
Anal squamous intraepithelial lesions: relation to HIV and human papillomavirus infection. J Acquir Immune Defic Syndr. 1999 Aug 1; 21 Suppl 1:S42-8.
Regulation of Epstein-Barr virus promoters in oral epithelial cells and lymphocytes. J Virol. 1999 Aug; 73(8):6566-72.
CD4-positive and CD8-positive cytotoxic T lymphocytes contribute to human papillomavirus type 16 E6 and E7 responses. Clin Diagn Lab Immunol. 1999 Jul; 6(4):494-8.
The clinical effectiveness and cost-effectiveness of screening for anal squamous intraepithelial lesions in homosexual and bisexual HIV-positive men. JAMA. 1999 May 19; 281(19):1822-9.
Prevalence and predictors of squamous cell abnormalities in Papanicolaou smears from women infected with HIV-1. Women's Interagency HIV Study Group. J Acquir Immune Defic Syndr. 1999 May 1; 21(1):33-41.
Cervicovaginal human papillomavirus infection in human immunodeficiency virus-1 (HIV)-positive and high-risk HIV-negative women. J Natl Cancer Inst. 1999 Feb 3; 91(3):226-36.
Risk factors for abnormal anal cytology in young heterosexual women. Cancer Epidemiol Biomarkers Prev. 1999 Feb; 8(2):173-8.
Papillary lesions of the anal canal. J Low Genit Tract Dis. 1999 Jan; 3(1):36.
Anal squamous intraepithelial lesions in HIV-positive and HIV-negative homosexual and bisexual men: prevalence and risk factors. J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Apr 1; 17(4):320-6.
Virologic, immunologic, and clinical parameters in the incidence and progression of anal squamous intraepithelial lesions in HIV-positive and HIV-negative homosexual men. J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Apr 1; 17(4):314-9.
High incidence of anal high-grade squamous intra-epithelial lesions among HIV-positive and HIV-negative homosexual and bisexual men. AIDS. 1998 Mar 26; 12(5):495-503.
Prevalence and risk factors for human papillomavirus infection of the anal canal in human immunodeficiency virus (HIV)-positive and HIV-negative homosexual men. J Infect Dis. 1998 Feb; 177(2):361-7.
The natural history of human papillomavirus infection as measured by repeated DNA testing in adolescent and young women. J Pediatr. 1998 Feb; 132(2):277-84.
Human papillomavirus infection and anogenital neoplasia in human immunodeficiency virus-positive men and women. J Natl Cancer Inst Monogr. 1998; (23):15-20.
Expression of Epstein-Barr virus BMRF-2 and BDLF-3 genes in hairy leukoplakia. J Gen Virol. 1997 Dec; 78 ( Pt 12):3361-70.
HPV detection in children prior to sexual debut. Int J Cancer. 1997 Nov 27; 73(5):621-4.
Epithelial-stromal interactions modulating penetration of matrigel membranes by HPV 16-immortalized keratinocytes. J Invest Dermatol. 1997 Nov; 109(5):619-25.
Colposcopic appearance of anal squamous intraepithelial lesions: relationship to histopathology. Dis Colon Rectum. 1997 Aug; 40(8):919-28.
Comparison of conventional cytologic smears and ThinPrep preparations from the anal canal. Acta Cytol. 1997 Jul-Aug; 41(4):1167-70.
Anal cytological abnormalities and anal HPV infection in men with Centers for Disease Control group IV HIV disease. Genitourin Med. 1997 Jun; 73(3):174-80.
Cutaneous squamous cell carcinoma in human immunodeficiency virus-infected patients. A study of epidemiologic risk factors, human papillomavirus, and p53 expression. Arch Dermatol. 1997 May; 133(5):577-83.
Epstein-Barr virus BMRF-2 and BDLF-3 expression in hairy leukoplakia. Oral Dis. 1997 May; 3 Suppl 1:S171-6.
Cutaneous and genital HPV-associated lesions in HIV-infected patients. Clin Dermatol. 1997 May-Jun; 15(3):439-47.
Anal cytology as a screening tool for anal squamous intraepithelial lesions. J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Apr 15; 14(5):415-22.
Cytotoxic T lymphocyte responses to E6 and E7 proteins of human papillomavirus type 16: relationship to cervical intraepithelial neoplasia. J Infect Dis. 1997 Apr; 175(4):927-31.
HPV infection and disease in men. Obstet Gynecol Clin North Am. 1996 Dec; 23(4):895-916.
Anal and cervical abnormality in women--prediction by human papillomavirus tests. Int J Cancer. 1996 Nov 27; 68(5):559-64.
Anal neoplasia. Pathogenesis, diagnosis, and management. Hematol Oncol Clin North Am. 1996 Oct; 10(5):1177-87.
T-cell proliferative response to human papillomavirus type 16 peptides: relationship to cervical intraepithelial neoplasia. Clin Diagn Lab Immunol. 1996 Mar; 3(2):205-10.
Type-specific prevalence of human papillomavirus DNA among Jamaican colposcopy patients. J Infect Dis. 1996 Mar; 173(3):718-21.
Sequence variation of latent membrane protein-1 of Epstein-Barr virus strains associated with hairy leukoplakia. J Infect Dis. 1996 Mar; 173(3):710-4.
Human papillomavirus-associated malignancies in HIV-positive men and women. Curr Opin Oncol. 1995 Sep; 7(5):437-41.
Urokinase plasminogen activator expression by primary and HPV 16-transformed keratinocytes. Clin Exp Metastasis. 1995 Jul; 13(4):260-8.
Molecular virology and epidemiology of human papillomavirus and cervical cancer. Cancer Epidemiol Biomarkers Prev. 1995 Jun; 4(4):415-28.
Association between proliferative verrucous leukoplakia and infection with human papillomavirus type 16. J Oral Pathol Med. 1995 May; 24(5):193-7.
Human T-cell lymphotropic virus type I and severe neoplasia of the cervix in Jamaica. Int J Cancer. 1995 Mar 29; 61(1):23-6.
Serologic detection of human papillomavirus-related anogenital disease: new opportunities and challenges. J Natl Cancer Inst. 1995 Mar 15; 87(6):401-2.
Risk factors for anal human papillomavirus infection and anal cytologic abnormalities in HIV-positive and HIV-negative homosexual men. J Acquir Immune Defic Syndr. 1994 Jun; 7(6):599-606.
Anal human papillomavirus infection and anal cancer in HIV-positive individuals: an emerging problem. AIDS. 1994 Mar; 8(3):283-95.
Detection of human papillomavirus type 16/18 DNA in cervicovaginal cells by fluorescence based in situ hybridization and automated image cytometry. Cytometry. 1994 Mar 1; 15(3):245-57.
Anal and cervical human papillomavirus infection and risk of anal and cervical epithelial abnormalities in human immunodeficiency virus-infected women. Obstet Gynecol. 1994 Feb; 83(2):205-11.
Variability of human papillomavirus DNA testing in a longitudinal cohort of young women. Obstet Gynecol. 1993 Oct; 82(4 Pt 1):578-85.
In vitro model of Haemophilus ducreyi adherence to and entry into eukaryotic cells of genital origin. J Infect Dis. 1993 Mar; 167(3):642-50.
Comparison between colposcopic, cytologic, and histologic findings in women positive and negative for human papillomavirus DNA. J Adolesc Health. 1993 Mar; 14(2):74-9.
Factors related to risk of penile cancer: new evidence from a study in the Pacific Northwest. J Natl Cancer Inst. 1993 Jan 6; 85(1):2-4.
Natural history of anal cytologic abnormalities and papillomavirus infection among homosexual men with group IV HIV disease. J Acquir Immune Defic Syndr. 1992 Dec; 5(12):1258-65.
Colposcopic and histologic findings and human papillomavirus (HPV) DNA test variability in young women positive for HPV DNA. J Infect Dis. 1992 Nov; 166(5):951-7.
Chronic verrucous varicella-zoster virus infection in patients with the acquired immunodeficiency syndrome (AIDS). Histologic and molecular biologic findings. Am J Dermatopathol. 1992 Feb; 14(1):1-7.
Human papillomavirus-associated anogenital neoplasia in persons with HIV infection. AIDS Clin Rev. 1992; 241-59.
Human papillomavirus-associated anogenital neoplasia and other solid tumors in human immunodeficiency virus-infected individuals. Curr Opin Oncol. 1991 Oct; 3(5):881-5.
The association between human papillomavirus deoxyribonucleic acid status and the results of cytologic rescreening tests in young, sexually active women. Am J Obstet Gynecol. 1991 Jul; 165(1):67-71.
Characterization of in vivo expression of the human papillomavirus type 16 E4 protein in cervical biopsy tissues. J Clin Invest. 1991 Jun; 87(6):2132-41.
Human papillomavirus infection among HIV-infected individuals. Implications for development of malignant tumors. Hematol Oncol Clin North Am. 1991 Apr; 5(2):357-70.
Detection of human papillomavirus DNA in anal intraepithelial neoplasia and anal cancer. Cancer Res. 1991 Feb 1; 51(3):1014-9.
Human papillomavirus infection in sexually active adolescent females: prevalence and risk factors. Pediatr Res. 1990 Nov; 28(5):507-13.
Immune status as a determinant of human papillomavirus detection and its association with anal epithelial abnormalities. Int J Cancer. 1990 Aug 15; 46(2):203-6.
Interaction of human immunodeficiency and papilloma viruses: association with anal epithelial abnormality in homosexual men. Int J Cancer. 1990 Aug 15; 46(2):214-9.
Anal intraepithelial neoplasia and anal papillomavirus infection among homosexual males with group IV HIV disease. JAMA. 1990 Jun 6; 263(21):2911-6.
Pathology: human papillomavirus infection and cervical neoplasia. West J Med. 1986 Sep; 145(3):377-8.
Influenza B virus PB1 protein; nucleotide sequence of the genome RNA segment predicts a high degree of structural homology with the corresponding influenza A virus polymerase protein. Virology. 1986 Jul 15; 152(1):126-35.
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